줄기세포정보 및 정책

줄기세포 R&D 동향

[임상연구 동향] 글로벌 줄기세포 임상 현황

한국줄기세포학회

view : 2850

검색조건 (stem cells | Recruiting, Not yet recruiting, Active, not recruiting, Completed, Enrolling by invitation,
Suspended, Terminated Studies | Phase Early Phase 1, 1, 2, 3)
Clinicaltrials.gov에서 등록된 줄기세포 치료 임상연구(Early Phase 1~ Phase 3) 중 중도포기와 시험단계가 알려지지 않은 연구를 제외하고 총 5,049개의 연구가 등록되어 있습니다.
01

[그림1. 글로벌 줄기세포 임상시험 현황]

검색조건 (stem cells | Recruiting, Not yet recruiting, Active, not recruiting, Completed, Enrolling by invitation,
Suspended, Terminated Studies | Phase Early Phase 1, 1, 2, 3| Start date on or after 01/01/2020)
이중 최근 2년인 2020년 1월 1일 이후로 현재까지 clinicaltrials.gov에 줄기세포를 활용한 등록된 임상연구는 818건으로 확인되었습니다.
02

[그림2. 2020년 이후 글로벌 줄기세포 임상시험 현황]

최근 2년간 수행되고 있는 임상시험의 조건 혹은 질환에 대해 항목별로 살펴본 결과 22개의 조건 혹은 질환에 대한 연구가 수행되고 있었습니다.

03

[그림3. 2020년 이후 글로벌 줄기세포의 질환 혹은 진단]

이러한 줄기세포 치료제 개발을 목표로 수행되는 임상시험에 사용되는 줄기세포는 종류는 다음과 같이 다양한 줄기세포를 활용되고 있음을 알 수있습니다.

치료제로 활용되는 줄기세포
Expanded autologous bone marrow-derived mesenchymal stem cell
Mesenchymal Stem Cells
Autologous Non-Hematopoietic Peripheral Blood Stem Cells (NHPBSC)
Olfactory mucosa-derived mesenchymal stem cells
Umbilical Cord Derived Mesenchymal Stem Cell (UC -MSC) Transplantation
Allogeneic Umbilical Cord Mesenchymal Stem Cell
Wharton Jelly Mesenchymal stem cells
Pooled mesenchymal stem cell
Neural Stem Cells
adipose-derived mesenchymal stem cells
limbal stem cells

마지막으로 818개의 임상을 모두 제공하기 어려워 그중 검색해서 제시된 상단 20개를 정리하였습니다.

NCT NumberStudy TitleStatusInterventionsSponsor/ Collaborators PhasesFunded BysStudy StartLocations
NCT04519671 Mesenchymal Stem Cells for the Treatment of Perianal Fistulizing Crohn's Disease Recruiting Drug: Mesenchymal Stem Cells Other: Placebo Amy Lightner The Cleveland Clinic Phase 1 Phase 2 Other 19-Nov-20 USA
NCT04519697 Mesenchymal Stem Cells for the Treatment of Rectovaginal Fistulas in Participants With Crohn's Disease Recruiting Drug: Mesenchymal Stem Cells Other: Placebo Amy Lightner The Cleveland Clinic Phase 1 Phase 2 Other 28-Oct-20 USA
NCT04473170 Study Evaluating the Safety and Efficacy of Autologous Non-Hematopoietic Peripheral Blood Stem Cells in COVID-19 Completed Biological: Autologous Non-Hematopoietic Peripheral Blood Stem Cells (NHPBSC) Drug: COVID-19 standard care Abu Dhabi Stem Cells Center Abu Dhabi Stem Cells Center Phase 1 Phase 2 Other 04-Apr-20 UAE
NCT04519684 Study of Mesenchymal Stem Cells for the Treatment of Ileal Pouch Fistula's in Participants With Crohn's Disease Recruiting Drug: Mesenchymal stem cells Other: Placebo Amy Lightner The Cleveland Clinic Phase 1 Phase 2 Other 28-Oct-20 USA
NCT04776239 Allogeneic Mesenchymal Human Stem Cell Infusion Therapy for Endothelial DySfunctiOn in Diabetic Subjects With Symptomatic Ischemic Heart Disease. (ACESO-IHD) Recruiting Drug: 100 million Allogeneic Mesenchymal Human Stem Cells Other: Placebo Joshua M Hare National Heart, Lung, and Blood Institute (NHLBI) University of Miami Phase 1 Phase 2 Other / NIH 16-Aug-21 USA
NCT04441658 Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cells Transplantation in Patients With Type 2 Diabetes Mellitus Recruiting Biological: Umbilical Cord Mesenchymal Stem Cells Biological: saline Shanghai East Hospital Phase 1 Phase 2 Other 10-Apr-20 China
NCT04446897 Treatment of Chronic Medium-severe Periodontitis With Mesenchymal Stem Cells Predifferentiated in Osteogenic Direction Completed

Biological: mesenchymal stem cells

Other: standard treatment 

Institute of Biophysics and Cell Engineering

Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus Belarusian Medical Academy of Post-Graduate Education  

Phase 1

Phase 2 

Other 03-Aug-20 Belarus
NCT04972890 The Outcomes of Intracavernosal Umbilical Cord Mesenchymal Stem Cells Implantation in Patients With Diabetic Erectile Dysfunction Recruiting Biological: stem cells Other: placebo Indonesia University Phase 2 Phase 3 Other 27-Oct-20 Indonesia
NCT04194671 Clinical Trial of Mesenchymal Stem Cells in the Treatment of Severe Acute Kidney Injury Not yet recruiting Biological: Mesenchymal stem cells Other: Saline Chinese PLA General Hospital Phase 1 Phase 2 Other 31-Dec-21 China
NCT04125329 Umbilical Cord Mesenchymal Stem Cells Therapy for Diabetic Nephropathy Recruiting Drug: Human umbilical cord mesenchymal stem cells Yan'an Affiliated Hospital of Kunming Medical University Early Phase 1 Other 01-Apr-20 China
NCT NumberStudy TitleStatusInterventionsSponsor/ Collaborators PhasesFunded BysStudy StartLocations
NCT05019287 Menstrual Blood Stem Cells in Severe Covid-19 Completed Biological: Allogeneic human menstrual blood stem cells secretome Other: Intravenous saline injection Avicenna Research Institute Tehran University of Medical Sciences Phase 1 Phase 2 Other 17-Apr-21 Iran
NCT03184935 Research for Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Myelodysplastic Syndrome (MDS) Suspended Biological: Allogeneic umbilical cord mesenchymal stem cells Drug: Decitabine Sclnow Biotechnology Co., Ltd. Phase 1 Phase 2 Industry Oct-21 China
NCT04314687 Stem Cell and Conditioned Medium for Cerebral Palsy Recruiting Biological: Umbilical Cord Mesenchymal Stem Cells Biological: Conditioned Medium Other: Standard Therapy

PT. Prodia Stem Cell Indonesia 

PT. Prodia Stem Cell Indonesia

Phase 1 Phase 2 Industry 25-Jun-20 Indonesia
NCT03180463 The Study of Early Stage Osteonecrosis of Femoral Head With Human Umbilical Cord Mesenchymal Stem Cells Suspended Drug: Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#) Procedure: core decompression Sclnow Biotechnology Co., Ltd. Phase 1 Phase 2 Industry Oct-21 China
NCT05075811 Study of Ossium Mesenchymal Stem Cells for the Treatment of Pouch Fistulas in the Setting of Crohn's Disease Not yet recruiting Drug: Ossium vBM-MSC Other: Placebo Amy Lightner Ossium Health, Inc. The Cleveland Clinic Phase 1 Phase 2 Other / Industry 15-Nov-21 USA
NCT05008588 Combination of Conditioned Medium and Umbilical Cord-Mesenchymal Stem Cells Therapy for Sub-Acute Stroke Infarct Not yet recruiting Biological: Conditioned Medium Biological: Umbilical Cord Mesenchymal Stem Cells Procedure: Neurologic and Neutrophic Drugs

PT. Prodia Stem Cell Indonesia 

PT. Prodia Stem Cell Indonesia

Phase 1 Phase 2 Industry Sep-21 Indonesia
NCT04432467 Fertility Restoration Using Autologous Mesenchymal Stem Cells Completed Biological: Autologous mesenchymal stem cells Other: standard treatment Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus Belarusian Medical Academy of Post-Graduate Education Phase 1 Phase 2 Other 01-Oct-20 Belarus
NCT04631406 A Safety and Tolerability Study of Neural Stem Cells (NR1) in Subjects With Chronic Ischemic Subcortical Stroke (ISS) Recruiting Biological: Neural Stem Cells Gary Steinberg California Institute for Regenerative Medicine (CIRM) Stanford University Phase 1 Phase 2 Other 04-Jan-21 USA
NCT04651855 The Evaluation of the Effect of Mesenchymal Stem Cells on the Immune System of Patients With ALS Recruiting Drug: Mesenchymal stem cells isolated from Wharton's jelly

Polski Bank Komorek Macierzystych JSC (PBKM)

National Center for Research and Development, Poland 

Phase 1 Phase 2 Industry / Other 02-Dec-20 Poland
NCT04661644 Efficacy and Safety of Mesenchymal Stem Cell Clusters in Patients With Critical Limb Ischemia Recruiting Biological: Clusters of adipose-derived mesenchymal stem cells (Dose: 1 x 10^7 cells/1 mL/vial) Biological: Clusters of adipose-derived mesenchymal stem cells (Dose: 1 x 10^8 cells/1 mL/vial) S.Biomedics Co., Ltd. Dt&Sanomedics Phase 1 Phase 2 Industry 04-Nov-20 Korea

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