Mission of the ISSCR’s Clinical Translation Committee

• Develop a strong and active translational and clinical presence within the ISSCR that reflects its growing impact within society.

• Provide leadership and develop strategy for the programs that support scientists, physicians, regulatory agencies and industry in the translation and development of stem cell-based therapies.

• Provide leadership in and support for developing programs and messages for the public on the application and use of stem cell-based therapies in a scientifically rigorous and ethical manner

Significant activities of the ISSCR’s Clinical Translation Committee

• Practical Advice for Physicians and Ethics / Institutional Review Committees. The ISSCR's "Stem Cell-Based Clinical Trials: Practical Advice for Physicians and Ethics/Institutional Review Committees" provides background and fundamental questions for clinicians and ethics / institutional review committees to ask when considering running or reviewing early phase, cell-based clinical trials.

https://www.isscr.org/scientific-clinical-resources/stem-cell-based-clinical-trials

• Disease Fact Sheets. These physician-focused, concise highlights provide the current state of stem cell science for specific diseases, including background on the disease, rationale for using cell-based therapies, evidence for specific approaches and current status of the field with respect to clinical trials. There are currently fact sheets on 11 different diseases.

https://www.isscr.org/scientific-clinical-resources/disease-fact-sheets

• Disease Fact Sheets. The fact sheets for physicians were “translated” to be suitable to public understanding and placed on the ISSCR’s public website, A Closer Look at Stem Cells.

https://www.closerlookatstemcells.org/stem-cells-medicine/disease-fact-sheets/

• Advising on ISSCR on translationally-related activities as needed. This includes:

   ° Meeting content, such as the Workshop on Clinical Translation

   ° Informed Consent Standard for Stem Cell-Based Interventions. This document outlines a professional standard  for the information that needs to be provided to patients (or their legally valid surrogates) to help position them to make an informed decision if offered stem cell-based interventions outside of a formal clinical trial. https://www.isscr.org/scientific-clinical-resources/informed-consent-standard-for-stem-cell-based-interventions